Can I take magnesium while on antidepressants?
4 The study also found that the participants who were taking an antidepressant experienced stronger benefits when taking magnesium, which suggests that it might be useful when used in conjunction with antidepressant medications. What supplements should not be taken with antidepressants? Supplements that contain serotonin or alter serotonin metabolism—such as 5HTP (a serotonin precursor), SAMe, or St John's Wort can cause (the potentially life-threatening) serotonin syndrome when taken with SSRIs. What medications should you not take with magnesium?